Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response...
Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Mycolactone is the exotoxin virulence factor of
Mycobacterium ulcerans
that causes the neglected tropical disease Buruli ulcer. We recently showed it to be a broad spectrum inhibitor of Sec61-dependent co-translational translocation of proteins into the endoplasmic reticulum (ER). An outstanding question is the molecular pathway linking this...
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Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5852046
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5852046
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-018-0427-y
