A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium...
A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation
About this item
Full title
Author / Creator
Murphy, Sean C , Duke, Elizabeth R , Shipman, Kelly J , Jensen, Ryan L , Fong, Youyi , Ferguson, Sue , Janes, Holly E , Gillespie, Kevin , Seilie, Annette M , Hanron, Amelia E , Rinn, Laurie , Fishbaugher, Matthew , VonGoedert, Tracie , Fritzen, Emma , Kappe, Stefan H , Chang, Ming , Sousa, Jason C , Marcsisin, Sean R , Chalon, Stephan , Duparc, Stephan , Kerr, Nicola , Möhrle, Jörg J , Andenmatten, Nicole , Rueckle, Thomas and Kublin, James G
Publisher
US: Oxford University Press
Journal title
Language
English
Formats
Publication information
Publisher
US: Oxford University Press
Subjects
More information
Scope and Contents
Contents
Abstract
Background
DSM265 is a selective inhibitor of Plasmodium dihydroorotate dehydrogenase that fully protected against controlled human malarial infection (CHMI) by direct venous inoculation of Plasmodium falciparum sporozoites when administered 1 day before challenge and provided partial protection when administered 7 days before challe...
Alternative Titles
Full title
A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation
Authors, Artists and Contributors
Author / Creator
Duke, Elizabeth R
Shipman, Kelly J
Jensen, Ryan L
Fong, Youyi
Ferguson, Sue
Janes, Holly E
Gillespie, Kevin
Seilie, Annette M
Hanron, Amelia E
Rinn, Laurie
Fishbaugher, Matthew
VonGoedert, Tracie
Fritzen, Emma
Kappe, Stefan H
Chang, Ming
Sousa, Jason C
Marcsisin, Sean R
Chalon, Stephan
Duparc, Stephan
Kerr, Nicola
Möhrle, Jörg J
Andenmatten, Nicole
Rueckle, Thomas
Kublin, James G
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5853383
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5853383
Other Identifiers
ISSN
0022-1899
E-ISSN
1537-6613
DOI
10.1093/infdis/jix613
