Nitric Oxide-Induced Apoptosis in Pancreatic β Cells is Mediated by the Endoplasmic Reticulum Stress...
Nitric Oxide-Induced Apoptosis in Pancreatic β Cells is Mediated by the Endoplasmic Reticulum Stress Pathway
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Excessive nitric oxide (NO) production in cytokine-activated β cells has been implicated in β cell disruption in type 1 diabetes. β cells are very vulnerable to NO-induced apoptosis. However, the mechanism underlying this phenomenon is unclear. Low concentrations of NO that lead to apoptosis apparently do not cause severe DNA damage in mouse MIN6 β...
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Full title
Nitric Oxide-Induced Apoptosis in Pancreatic β Cells is Mediated by the Endoplasmic Reticulum Stress Pathway
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_58562
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_58562
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.191207498
