Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema
Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Chronic obstructive pulmonary disease affects 10% of the worldwide population, and the leading genetic cause is α-1 antitrypsin (AAT) deficiency. Due to the complexity of the murine locus, which includes up to six Serpina1 paralogs, no genetic animal model of the disease has been successfully generated until now. Here we create a quintuple Serpina1...
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Full title
Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5856518
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5856518
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1713689115
