An environment-dependent transcriptional network specifies human microglia identity
An environment-dependent transcriptional network specifies human microglia identity
About this item
Full title
Author / Creator
Gosselin, David , Skola, Dylan , Coufal, Nicole G. , Holtman, Inge R. , Schlachetzki, Johannes C. M. , Sajti, Eniko , Jaeger, Baptiste N. , O’Connor, Carolyn , Fitzpatrick, Conor , Pasillas, Martina P. , Pena, Monique , Adair, Amy , Gonda, David D. , Levy, Michael L. , Ransohoff, Richard M. , Gage, Fred H. and Glass, Christopher K.
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Microglia play essential roles in central nervous system (CNS) homeostasis and influence diverse aspects of neuronal function. However, the transcriptional mechanisms that specify human microglia phenotypes are largely unknown. We examined the transcriptomes and epigenetic landscapes of human microglia isolated from surgically resected brain tissue...
Alternative Titles
Full title
An environment-dependent transcriptional network specifies human microglia identity
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5858585
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5858585
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aal3222
