Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltran...
Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Methylation at the 5 position of cytosine in DNA (5meC) is a key epigenetic mark in eukaryotes. Once introduced, 5meC can be maintained through DNA replication by the activity of ‘maintenance’ DNA methyltransferases (DNMTs). Despite their ancient origin, DNA methylation pathways differ widely across animals, such that 5meC is either confined to tra...
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Full title
Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5865749
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5865749
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-018-0061-8
