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Placentation defects are highly prevalent in embryonic lethal mouse mutants

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Placentation defects are highly prevalent in embryonic lethal mouse mutants

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5866719

Placentation defects are highly prevalent in embryonic lethal mouse mutants

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Publisher

London: Nature Publishing Group UK

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Contents

Large-scale phenotyping efforts have demonstrated that approximately 25–30% of mouse gene knockouts cause intrauterine lethality. Analysis of these mutants has largely focused on the embryo and not the placenta, despite the crucial role of this extraembryonic organ for developmental progression. Here we screened 103 embryonic lethal and sub-viable...

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Full title

Placentation defects are highly prevalent in embryonic lethal mouse mutants

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Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5866719

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5866719

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature26002

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