A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation
A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation
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Publisher
United States: The American Association for the Advancement of Science
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Language
English
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United States: The American Association for the Advancement of Science
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Contents
The ATR (ataxia telangiectasia mutated and Rad3-related) kinase plays important roles in the S phase and during the DNA damage response to safeguard genome integrity. Kabeche
et al.
identified a distinct ATR activation pathway in mitosis that is also critical for suppressing genome instability (see the Perspective by Saldivar and Cimprich). A...
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Full title
A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5875943
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5875943
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aan6490
