A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation
A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation
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Publisher
United States: The American Association for the Advancement of Science
Journal title
Language
English
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United States: The American Association for the Advancement of Science
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Contents
The ataxia telangiectasia mutated and Rad3-related (ATR) kinase is crucial for DNA damage and replication stress responses. Here, we describe an unexpected role of ATR in mitosis. Acute inhibition or degradation of ATR in mitosis induces whole-chromosome missegregation. The effect of ATR ablation is not due to altered cyclin-dependent kinase 1 (CDK...
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Full title
A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5875943
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5875943
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aan6490
