Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-f...
Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form
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Author / Creator
Argonne National Laboratory (ANL), Argonne, IL (United States) , Nelp, Micah T. , Kates, Patrick A. , Hunt, John T. , Newitt, John A. , Balog, Aaron , Maley, Derrick , Zhu, Xiao , Abell, Lynn , Allentoff, Alban , Borzilleri, Robert , Lewis, Hal A. , Lin, Zeyu , Seitz, Steven P. , Yan, Chunhong and Groves, John T.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
For cancer cells to survive and proliferate, they must escape normal immune destruction. One mechanism by which this is accomplished is through immune suppression effected by up-regulation of indoleamine 2,3-dioxygenase (IDO1), a heme enzyme that catalyzes the oxidation of tryptophan to N-formylkynurenine. On deformylation, kynurenine and downstrea...
Alternative Titles
Full title
Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5879690
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5879690
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1719190115
