Radically truncated MeCP2 rescues Rett syndrome-like neurological defects
Radically truncated MeCP2 rescues Rett syndrome-like neurological defects
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Analysis of the minimal functional unit for MeCP2 protein shows that its function is to recruit the NCoR/SMRT co-repressor complex to methylated sites on chromatin, which may have use in designing strategies for gene therapy of Rett syndrome.
MeCP2 to the Rett-scue
Rett syndrome is a neurological disorder caused by mutations in the
MECP2
Alternative Titles
Full title
Radically truncated MeCP2 rescues Rett syndrome-like neurological defects
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5884422
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5884422
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature24058
