TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD
TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD
About this item
Full title
Author / Creator
White, Matthew A. , Kim, Eosu , Duffy, Amanda , Adalbert, Robert , Phillips, Benjamin U. , Peters, Owen M. , Stephenson, Jodie , Yang, Sujeong , Massenzio, Francesca , Lin, Ziqiang , Andrews, Simon , Segonds-Pichon, Anne , Metterville, Jake , Saksida, Lisa M. , Mead, Richard , Ribchester, Richard R , Barhomi, Youssef , Serre, Thomas , Coleman, Michael P. , Fallon, Justin R. , Bussey, Timothy J. , Brown, Robert H. and Sreedharan, Jemeen
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Amyotrophic lateral sclerosis–frontotemporal dementia (ALS-FTD) constitutes a devastating disease spectrum characterized by 43-kDa TAR DNA-binding protein (TDP-43) pathology. Understanding how TDP-43 contributes to neurodegeneration will help direct therapeutic efforts. Here we have created a TDP-43 knock-in mouse with a human-equivalent mutation i...
Alternative Titles
Full title
TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD
Authors, Artists and Contributors
Author / Creator
Kim, Eosu
Duffy, Amanda
Adalbert, Robert
Phillips, Benjamin U.
Peters, Owen M.
Stephenson, Jodie
Yang, Sujeong
Massenzio, Francesca
Lin, Ziqiang
Andrews, Simon
Segonds-Pichon, Anne
Metterville, Jake
Saksida, Lisa M.
Mead, Richard
Ribchester, Richard R
Barhomi, Youssef
Serre, Thomas
Coleman, Michael P.
Fallon, Justin R.
Bussey, Timothy J.
Brown, Robert H.
Sreedharan, Jemeen
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5884423
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5884423
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/s41593-018-0113-5
