Salinomycin kills cancer stem cells by sequestering iron in lysosomes
Salinomycin kills cancer stem cells by sequestering iron in lysosomes
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Author / Creator
Mai, Trang Thi , Hamaï, Ahmed , Hienzsch, Antje , Cañeque, Tatiana , Müller, Sebastian , Wicinski, Julien , Cabaud, Olivier , Leroy, Christine , David, Amandine , Acevedo, Verónica , Ryo, Akihide , Ginestier, Christophe , Birnbaum, Daniel , Charafe-Jauffret, Emmanuelle , Codogno, Patrice , Mehrpour, Maryam and Rodriguez, Raphaël
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Cancer stem cells (CSCs) represent a subset of cells within tumours that exhibit self-renewal properties and the capacity to seed tumours. CSCs are typically refractory to conventional treatments and have been associated to metastasis and relapse. Salinomycin operates as a selective agent against CSCs through mechanisms that remain elusive. Here, w...
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Full title
Salinomycin kills cancer stem cells by sequestering iron in lysosomes
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5890907
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5890907
Other Identifiers
ISSN
1755-4330,1755-4349
E-ISSN
1755-4349
DOI
10.1038/nchem.2778
