Live-Attenuated Respiratory Syncytial Virus Vaccine Candidate With Deletion of RNA Synthesis Regulat...
Live-Attenuated Respiratory Syncytial Virus Vaccine Candidate With Deletion of RNA Synthesis Regulatory Protein M2-2 is Highly Immunogenic in Children
About this item
Full title
Author / Creator
International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) 2000 Study Team , McFarland, Elizabeth J , Karron, Ruth A , Muresan, Petronella , Cunningham, Coleen K , Valentine, Megan E , Perlowski, Charlotte , Thumar, Bhagvanji , Gnanashanmugam, Devasena , Siberry, George K , Schappell, Elizabeth , Barr, Emily , Rexroad, Vivian , Yogev, Ram , Spector, Stephen A , Aziz, Mariam , Patel, Nehali , Cielo, Mikhaela , Luongo, Cindy , Collins, Peter L and Buchholz, Ursula J
Publisher
US: Oxford University Press
Journal title
Language
English
Formats
Publication information
Publisher
US: Oxford University Press
Subjects
More information
Scope and Contents
Contents
Abstract
Background
Live respiratory syncytial virus (RSV) candidate vaccine LIDΔM2-2 is attenuated by deletion of the RSV RNA regulatory protein M2-2, resulting in upregulated viral gene transcription and antigen expression but reduced RNA replication.
Methods
RSV-seronegative children ages 6–24 months received a single intranasal dose...
Alternative Titles
Full title
Live-Attenuated Respiratory Syncytial Virus Vaccine Candidate With Deletion of RNA Synthesis Regulatory Protein M2-2 is Highly Immunogenic in Children
Authors, Artists and Contributors
Author / Creator
McFarland, Elizabeth J
Karron, Ruth A
Muresan, Petronella
Cunningham, Coleen K
Valentine, Megan E
Perlowski, Charlotte
Thumar, Bhagvanji
Gnanashanmugam, Devasena
Siberry, George K
Schappell, Elizabeth
Barr, Emily
Rexroad, Vivian
Yogev, Ram
Spector, Stephen A
Aziz, Mariam
Patel, Nehali
Cielo, Mikhaela
Luongo, Cindy
Collins, Peter L
Buchholz, Ursula J
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5894092
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5894092
Other Identifiers
ISSN
0022-1899
E-ISSN
1537-6613
DOI
10.1093/infdis/jiy040
