PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors
PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Necroptosis, a form of regulated necrotic cell death, is governed by RIP1/RIP3-mediated activation of MLKL. However, the signaling process leading to necroptotic death remains to be elucidated. In this study, we found that PUMA, a proapoptotic BH3-only Bcl-2 family member, is transcriptionally activated in an RIP3/MLKL-dependent manner following in...
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Full title
PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5899441
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5899441
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1717190115
