Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction...
Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2
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Publisher
England: The Royal Society
Journal title
Language
English
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Publisher
England: The Royal Society
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Scope and Contents
Contents
SIRT2 is a member of the human sirtuin family of proteins and possesses NAD+-dependent lysine deacetylase/deacylase activity. SIRT2 has been implicated in carcinogenesis in various cancers including leukaemia and is considered an attractive target for cancer therapy. Here, we identified NPD11033, a selective small-molecule SIRT2 inhibitor, by a hig...
Alternative Titles
Full title
Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5915714
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5915714
Other Identifiers
ISSN
0962-8436
E-ISSN
1471-2970
DOI
10.1098/rstb.2017.0070
