Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT in...
Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors
About this item
Full title
Author / Creator
Halby, Ludovic , Marechal, Nils , Pechalrieu, Dany , Cura, Vincent , Franchini, Don-Marc , Faux, Céline , Alby, Fréderic , Troffer-Charlier, Nathalie , Kudithipudi, Srikanth , Jeltsch, Albert , Aouadi, Wahiba , Decroly, Etienne , Guillemot, Jean-Claude , Page, Patrick , Ferroud, Clotilde , Bonnefond, Luc , Guianvarc'h, Dominique , Cavarelli, Jean and Arimondo, Paola B.
Publisher
England: The Royal Society
Journal title
Language
English
Formats
Publication information
Publisher
England: The Royal Society
Subjects
More information
Scope and Contents
Contents
DNA, RNA and histone methylation is implicated in various human diseases such as cancer or viral infections, playing a major role in cell process regulation, especially in modulation of gene expression. Here we developed a convergent synthetic pathway starting from a protected bromomethylcytosine derivative to synthesize transition state analogues...
Alternative Titles
Full title
Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors
Authors, Artists and Contributors
Author / Creator
Marechal, Nils
Pechalrieu, Dany
Cura, Vincent
Franchini, Don-Marc
Faux, Céline
Alby, Fréderic
Troffer-Charlier, Nathalie
Kudithipudi, Srikanth
Jeltsch, Albert
Aouadi, Wahiba
Decroly, Etienne
Guillemot, Jean-Claude
Page, Patrick
Ferroud, Clotilde
Bonnefond, Luc
Guianvarc'h, Dominique
Cavarelli, Jean
Arimondo, Paola B.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5915716
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5915716
Other Identifiers
ISSN
0962-8436
E-ISSN
1471-2970
DOI
10.1098/rstb.2017.0072
