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Killer cell immunoglobulin–like receptor 3DL1 variation modifies HLA-B57 protection against HIV-1

Killer cell immunoglobulin–like receptor 3DL1 variation modifies HLA-B57 protection against HIV-1

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5919796

Killer cell immunoglobulin–like receptor 3DL1 variation modifies HLA-B57 protection against HIV-1

About this item

Full title

Killer cell immunoglobulin–like receptor 3DL1 variation modifies HLA-B57 protection against HIV-1

Publisher

United States: American Society for Clinical Investigation

Journal title

The Journal of clinical investigation, 2018-05, Vol.128 (5), p.1903-1912

Language

English

Formats

Publication information

Publisher

United States: American Society for Clinical Investigation

More information

Scope and Contents

Contents

HLA-B*57 control of HIV involves enhanced CD8+ T cell responses against infected cells, but extensive heterogeneity exists in the level of HIV control among B*57+ individuals. Using whole-genome sequencing of untreated B*57+ HIV-1-infected controllers and noncontrollers, we identified a single variant (rs643347A/G) encoding an isoleucine-to-valine...

Alternative Titles

Full title

Killer cell immunoglobulin–like receptor 3DL1 variation modifies HLA-B57 protection against HIV-1

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5919796

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5919796

Other Identifiers

ISSN

0021-9738,1558-8238

E-ISSN

1558-8238

DOI

10.1172/JCI98463

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