High throughput evaluation of macrocyclization strategies for conformer stabilization
High throughput evaluation of macrocyclization strategies for conformer stabilization
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
While macrocyclization of a linear compound to stabilize a known bioactive conformation can be a useful strategy to increase binding potency, the difficulty of macrocycle synthesis can limit the throughput of such strategies. Thus computational techniques may offer the higher throughput required to screen large numbers of compounds. Here we introdu...
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Full title
High throughput evaluation of macrocyclization strategies for conformer stabilization
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5920116
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5920116
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-24766-5
