Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity
Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity
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Publisher
United States: The American Association for the Advancement of Science
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Language
English
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United States: The American Association for the Advancement of Science
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Contents
Dimethyl fumarate (DMF) is an immunomodulatory compound used to treat multiple sclerosis and psoriasis whose mechanisms of action remain only partially understood. Kornberg
et al.
found that DMF and its metabolite, monomethyl fumarate, succinate the glycolytic enzyme GAPDH (see the Perspective by Matsushita and Pearce). After DMF treatment, G...
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Full title
Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5924419
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5924419
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aan4665
