Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence
Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
REV-ERBs, nuclear hormone receptors that regulate transcription as part of the circadian clock cell machinery, inhibit autophagy and lipogenesis in premalignant and malignant cells and impair tumour growth
in vivo
.
Tumours restrained by REV-ERBs
The circadian clock regulates many of the physiological functions of an organism. Additiona...
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Full title
Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5924733
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5924733
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ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/nature25170
