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GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation

GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5924877

GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation

About this item

Full title

GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2018-04, Vol.115 (17), p.4501-4506

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

The growth hormone secretagogue receptor (GHSR) and dopamine receptor (D2R) have been shown to oligomerize in hypothalamic neurons with a significant effect on dopamine signaling, but the molecular processes underlying this effect are still obscure. We used here the purified GHSR and D2R to establish that these two receptors assemble in a lipid env...

Alternative Titles

Full title

GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5924877

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5924877

Other Identifiers

ISSN

0027-8424,1091-6490

E-ISSN

1091-6490

DOI

10.1073/pnas.1712725115

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