Biased signalling: from simple switches to allosteric microprocessors
Biased signalling: from simple switches to allosteric microprocessors
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Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Key Points
G protein-coupled receptors (GPCRs) adopt multiple conformational states that can activate or block distinct intracellular signalling pathways, such as those regulated by heterotrimeric G proteins or β-arrestins.
Different agonists for the same receptor can stabilize distinct GPCR conformational states. Agonists that preferentially...
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Full title
Biased signalling: from simple switches to allosteric microprocessors
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5936084
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5936084
Other Identifiers
ISSN
1474-1776
E-ISSN
1474-1784
DOI
10.1038/nrd.2017.229
