Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation
Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation
About this item
Full title
Author / Creator
Sun, Daxiao , Wu, Rongbo , Zheng, Jingxiang , Li, Pilong and Yu, Li
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Misfolded proteins can be degraded by selective autophagy. The prevailing view is that ubiquitin-tagged misfolded proteins are assembled into aggregates by the scaffold protein p62, and the aggregates are then engulfed and degraded by autophagosomes. Here we report that p62 forms droplets in vivo which have liquid-like properties such as high spher...
Alternative Titles
Full title
Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5939046
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5939046
Other Identifiers
ISSN
1001-0602
E-ISSN
1748-7838
DOI
10.1038/s41422-018-0017-7
