Mapping interactions with the chaperone network reveals factors that protect against tau aggregation
Mapping interactions with the chaperone network reveals factors that protect against tau aggregation
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Author / Creator
Mok, Sue-Ann , Condello, Carlo , Freilich, Rebecca , Gillies, Anne , Arhar, Taylor , Oroz, Javier , Kadavath, Harindranath , Julien, Olivier , Assimon, Victoria A. , Rauch, Jennifer N. , Dunyak, Bryan M. , Lee, Jungsoon , Tsai, Francis T. F. , Wilson, Mark R. , Zweckstetter, Markus , Dickey, Chad A. and Gestwicki, Jason E.
Publisher
New York: Nature Publishing Group US
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English
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Publisher
New York: Nature Publishing Group US
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Contents
A network of molecular chaperones is known to bind proteins (‘clients’) and balance their folding, function and turnover. However, it is often unclear which chaperones are critical for selective recognition of individual clients. It is also not clear why these key chaperones might fail in protein-aggregation diseases. Here, we utilized human microt...
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Full title
Mapping interactions with the chaperone network reveals factors that protect against tau aggregation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5942583
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5942583
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ISSN
1545-9993,1545-9985
E-ISSN
1545-9985
DOI
10.1038/s41594-018-0057-1
