Nitric Oxide-Independent Soluble Guanylate Cyclase Activation Improves Vascular Function and Cardiac...
Nitric Oxide-Independent Soluble Guanylate Cyclase Activation Improves Vascular Function and Cardiac Remodeling in Sickle Cell Disease
About this item
Full title
Author / Creator
Potoka, Karin P , Wood, Katherine C , Baust, Jeffrey J , Bueno, Marta , Hahn, Scott A , Vanderpool, Rebecca R , Bachman, Tim , Mallampalli, Grace M , Osei-Hwedieh, David O , Schrott, Valerie , Sun, Bin , Bullock, Grant C , Becker-Pelster, Eva-Maria , Wittwer, Matthias , Stampfuss, Jan , Mathar, Ilka , Stasch, Johannes-Peter , Truebel, Hubert , Sandner, Peter , Mora, Ana L , Straub, Adam C and Gladwin, Mark T
Publisher
United States: American Thoracic Society
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Thoracic Society
Subjects
More information
Scope and Contents
Contents
Sickle cell disease (SCD) is associated with intravascular hemolysis and oxidative inhibition of nitric oxide (NO) signaling. BAY 54-6544 is a small-molecule activator of oxidized soluble guanylate cyclase (sGC), which, unlike endogenous NO and the sGC stimulator, BAY 41-8543, preferentially binds and activates heme-free, NO-insensitive sGC to rest...
Alternative Titles
Full title
Nitric Oxide-Independent Soluble Guanylate Cyclase Activation Improves Vascular Function and Cardiac Remodeling in Sickle Cell Disease
Authors, Artists and Contributors
Author / Creator
Wood, Katherine C
Baust, Jeffrey J
Bueno, Marta
Hahn, Scott A
Vanderpool, Rebecca R
Bachman, Tim
Mallampalli, Grace M
Osei-Hwedieh, David O
Schrott, Valerie
Sun, Bin
Bullock, Grant C
Becker-Pelster, Eva-Maria
Wittwer, Matthias
Stampfuss, Jan
Mathar, Ilka
Stasch, Johannes-Peter
Truebel, Hubert
Sandner, Peter
Mora, Ana L
Straub, Adam C
Gladwin, Mark T
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5946331
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5946331
Other Identifiers
ISSN
1044-1549
E-ISSN
1535-4989
DOI
10.1165/rcmb.2017-0292OC
