Rebecca Fitzgerald and colleagues report the whole-genome sequences of 129 esophageal adenocarcinomas, showing frequent copy number alterations and prevalent mutations in receptor tyrosine kinases concomitant with mitogenic activation. They further characterize mutation signatures and find three distinct molecular subtypes with potential for applic...

Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance

10.1038/ng.3659