AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory respon...
AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) is an established pharmacological activator of AMP-activated protein kinase (AMPK). Both, AICAR and AMPK were reported to attenuate inflammation. However, AICAR is known for many AMPK-independent effects, although the mechanisms remain incompletely understood. Here we report a potent suppr...
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AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5958102
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5958102
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-26102-3
