Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of...
Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages
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Author / Creator
Muse, Evan D. , Yu, Shan , Edillor, Chantle R. , Tao, Jenhan , Spann, Nathanael J. , Troutman, Ty D. , Seidman, Jason S. , Henke, Adam , Roland, Jason T. , Ozeki, Katherine A. , Thompson, Bonne M. , McDonald, Jeffrey G. , Bahadorani, John , Tsimikas, Sotirios , Grossman, Tamar R. , Tremblay, Matthew S. and Glass, Christopher K.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models. Most synthetic LXR agonists also cause marked hypertriglyceridemia by inducing the expression of sterol regulatory element-binding protein (SREBP)1c and downstream genes that drive fatty acid bi...
Alternative Titles
Full title
Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5960280
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5960280
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1714518115
