Once and only once: mechanisms of centriole duplication and their deregulation in disease
Once and only once: mechanisms of centriole duplication and their deregulation in disease
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Key Points
Centrosome duplication is tightly regulated to ensure that centrioles duplicate only once per cell cycle and that only one new centriole is produced per pre-existing centriole
Phosphorylation events have an important role in controlling centriole number. Polo-like kinase 1 (PLK1) has a key function in cell cycle control of centriol...
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Full title
Once and only once: mechanisms of centriole duplication and their deregulation in disease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5969912
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5969912
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ISSN
1471-0072,1471-0080
E-ISSN
1471-0080
DOI
10.1038/nrm.2017.127
