Apoptotic cell–induced, TLR9-dependent AhR activity is required for immunological tolerance and supp...
Apoptotic cell–induced, TLR9-dependent AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans
About this item
Full title
Author / Creator
Shinde, Rahul , Hezaveh, Kebria , Halaby, Marie Jo , Kloetgen, Andreas , Chakravarthy, Ankur , da Silva Medina, Tiago , Deol, Reema , Manion, Kieran P. , Baglaenko, Yuriy , Eldh, Maria , Lamorte, Sara , Wallace, Drew , Chodisetti, Sathi Babu , Ravishankar, Buvana , Liu, Haiyun , Chaudhary, Kapil , Munn, David H. , Tsirigos, Aristotelis , Madaio, Michael , Gabrielsson, Susanne , Touma, Zahi , Wither, Joan , De Carvalho, Daniel D. and McGaha, Tracy L.
Journal title
Language
English
Formats
More information
Scope and Contents
Contents
The transcription factor AhR modulates immunity at multiple levels. Here we report phagocytes exposed to apoptotic cells exhibited rapid activation of AhR, which drove production of interleukin 10. Activation of AhR was dependent on interactions between apoptotic-cell DNA and the pattern-recognition receptor TLR9 that was required for prevention of...
Alternative Titles
Full title
Apoptotic cell–induced, TLR9-dependent AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans
Authors, Artists and Contributors
Author / Creator
Hezaveh, Kebria
Halaby, Marie Jo
Kloetgen, Andreas
Chakravarthy, Ankur
da Silva Medina, Tiago
Deol, Reema
Manion, Kieran P.
Baglaenko, Yuriy
Eldh, Maria
Lamorte, Sara
Wallace, Drew
Chodisetti, Sathi Babu
Ravishankar, Buvana
Liu, Haiyun
Chaudhary, Kapil
Munn, David H.
Tsirigos, Aristotelis
Madaio, Michael
Gabrielsson, Susanne
Touma, Zahi
Wither, Joan
De Carvalho, Daniel D.
McGaha, Tracy L.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5976527
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5976527
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-018-0107-1
