Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cy...
Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4
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Author / Creator
Lacy, Michael , Kontos, Christos , Brandhofer, Markus , Hille, Kathleen , Gröning, Sabine , Sinitski, Dzmitry , Bourilhon, Priscila , Rosenberg, Eric , Krammer, Christine , Thavayogarajah, Tharshika , Pantouris, Georgios , Bakou, Maria , Weber, Christian , Lolis, Elias , Bernhagen, Jürgen and Kapurniotu, Aphrodite
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
MIF is a chemokine-like cytokine that plays a role in the pathogenesis of inflammatory and cardiovascular disorders. It binds to the chemokine-receptors CXCR2/CXCR4 to trigger atherogenic leukocyte migration albeit lacking canonical chemokine structures. We recently characterized an N-like-loop and the Pro-2-residue of MIF as critical molecular det...
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Full title
Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5979958
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5979958
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-23554-5
