Blocking IFNAR1 inhibits multiple myeloma–driven Treg expansion and immunosuppression
Blocking IFNAR1 inhibits multiple myeloma–driven Treg expansion and immunosuppression
About this item
Full title
Author / Creator
Kawano, Yawara , Zavidij, Oksana , Park, Jihye , Moschetta, Michele , Kokubun, Katsutoshi , Mouhieddine, Tarek H. , Manier, Salomon , Mishima, Yuji , Murakami, Naoka , Bustoros, Mark , Pistofidis, Romanos Sklavenitis , Reidy, Mairead , Shen, Yu J. , Rahmat, Mahshid , Lukyanchykov, Pavlo , Karreci, Esilida Sula , Tsukamoto, Shokichi , Shi, Jiantao , Takagi, Satoshi , Huynh, Daisy , Sacco, Antonio , Tai, Yu-Tzu , Chesi, Marta , Bergsagel, P. Leif , Roccaro, Aldo M. , Azzi, Jamil and Ghobrial, Irene M.
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Despite significant advances in the treatment of multiple myeloma (MM), most patients succumb to disease progression. One of the major immunosuppressive mechanisms that is believed to play a role in myeloma progression is the expansion of regulatory T cells (Tregs). In this study, we demonstrate that myeloma cells drive Treg expansion and activatio...
Alternative Titles
Full title
Blocking IFNAR1 inhibits multiple myeloma–driven Treg expansion and immunosuppression
Authors, Artists and Contributors
Author / Creator
Zavidij, Oksana
Park, Jihye
Moschetta, Michele
Kokubun, Katsutoshi
Mouhieddine, Tarek H.
Manier, Salomon
Mishima, Yuji
Murakami, Naoka
Bustoros, Mark
Pistofidis, Romanos Sklavenitis
Reidy, Mairead
Shen, Yu J.
Rahmat, Mahshid
Lukyanchykov, Pavlo
Karreci, Esilida Sula
Tsukamoto, Shokichi
Shi, Jiantao
Takagi, Satoshi
Huynh, Daisy
Sacco, Antonio
Tai, Yu-Tzu
Chesi, Marta
Bergsagel, P. Leif
Roccaro, Aldo M.
Azzi, Jamil
Ghobrial, Irene M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5983341
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5983341
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI88169
