Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glio...
Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma
About this item
Full title
Author / Creator
Xu, Liang , Chen, Ye , Mayakonda, Anand , Koh, Lynnette , Chong, Yuk Kien , Buckley, Dennis L. , Sandanaraj, Edwin , Lim, See Wee , Lin, Ruby Yu-Tong , Ke, Xin-Yu , Huang, Mo-Li , Chen, Jianxiang , Sun, Wendi , Wang, Ling-Zhi , Goh, Boon Cher , Dinh, Huy Q. , Kappei, Dennis , Winter, Georg E. , Ding, Ling-Wen , Ang, Beng Ti , Berman, Benjamin P. , Bradner, James E. , Tang, Carol and Koeffler, H. Phillip
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Competitive BET bromodomain inhibitors (BBIs) targeting BET proteins (BRD2, BRD3, BRD4, and BRDT) show promising preclinical activities against brain cancers. However, the BET protein-dependent glioblastoma (GBM)-promoting transcriptional network remains elusive. Here, with mechanistic exploration of a next-generation chemical degrader of BET prote...
Alternative Titles
Full title
Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma
Authors, Artists and Contributors
Author / Creator
Chen, Ye
Mayakonda, Anand
Koh, Lynnette
Chong, Yuk Kien
Buckley, Dennis L.
Sandanaraj, Edwin
Lim, See Wee
Lin, Ruby Yu-Tong
Ke, Xin-Yu
Huang, Mo-Li
Chen, Jianxiang
Sun, Wendi
Wang, Ling-Zhi
Goh, Boon Cher
Dinh, Huy Q.
Kappei, Dennis
Winter, Georg E.
Ding, Ling-Wen
Ang, Beng Ti
Berman, Benjamin P.
Bradner, James E.
Tang, Carol
Koeffler, H. Phillip
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5984485
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5984485
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1712363115
