Association analysis in over 329,000 individuals identifies 116 independent variants influencing neu...
Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism
About this item
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Author / Creator
Luciano, Michelle , Hagenaars, Saskia P. , Davies, Gail , Hill, W. David , Clarke, Toni-Kim , Shirali, Masoud , Harris, Sarah E. , Marioni, Riccardo E. , Liewald, David C. , Fawns-Ritchie, Chloe , Adams, Mark J. , Howard, David M. , Lewis, Cathryn M. , Gale, Catharine R. , McIntosh, Andrew M. and Deary, Ian J.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Neuroticism is a relatively stable personality trait characterized by negative emotionality (for example, worry and guilt)
1
; heritability estimated from twin studies ranges from 30 to 50%
2
, and SNP-based heritability ranges from 6 to 15%
3
–
6
. Increased neuroticism is associated with poorer mental and physical health
Alternative Titles
Full title
Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5985926
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5985926
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-017-0013-8
