Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling
Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling
About this item
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Author / Creator
Mack, Stephen C. , Pajtler, Kristian W. , Chavez, Lukas , Okonechnikov, Konstantin , Bertrand, Kelsey C. , Wang, Xiuxing , Erkek, Serap , Federation, Alexander , Song, Anne , Lee, Christine , Wang, Xin , McDonald, Laura , Morrow, James J. , Saiakhova, Alina , Sin-Chan, Patrick , Wu, Qiulian , Michaelraj, Kulandaimanuvel Antony , Miller, Tyler E. , Hubert, Christopher G. , Ryzhova, Marina , Garzia, Livia , Donovan, Laura , Dombrowski, Stephen , Factor, Daniel C. , Luu, Betty , Valentim, Claudia L. L. , Gimple, Ryan C. , Morton, Andrew , Kim, Leo , Prager, Briana C. , Lee, John J. Y. , Wu, Xiaochong , Zuccaro, Jennifer , Thompson, Yuan , Holgado, Borja L. , Reimand, Jüri , Ke, Susan Q. , Tropper, Adam , Lai, Sisi , Vijayarajah, Senthuran , Doan, Sylvia , Mahadev, Vaidehi , Miñan, Ana Fernandez , Gröbner, Susanne N. , Lienhard, Matthias , Zapatka, Marc , Huang, Zhiqin , Aldape, Kenneth D. , Carcaboso, Angel M. , Houghton, Peter J. , Keir, Stephen T. , Milde, Till , Witt, Hendrik , Li, Yan , Li, Chao-Jun , Bian, Xiu-Wu , Jones, David T. W. , Scott, Ian , Singh, Sheila K. , Huang, Annie , Dirks, Peter B. , Bouffet, Eric , Bradner, James E. , Ramaswamy, Vijay , Jabado, Nada , Rutka, James T. , Northcott, Paul A. , Lupien, Mathieu , Lichter, Peter , Korshunov, Andrey , Scacheri, Peter C. , Pfister, Stefan M. , Kool, Marcel , Taylor, Michael D. and Rich, Jeremy N.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Super enhancers regulate oncogenes and other molecular targets in ependymomas, and identification of these genes provides potential therapeutic targets.
Targeting brain tumours
Ependymomas are chemotherapy-resistant brain tumours, which lack effective molecular targets for the development of therapeutics. Here, Jeremy Rich and colleagues map...
Alternative Titles
Full title
Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling
Authors, Artists and Contributors
Author / Creator
Pajtler, Kristian W.
Chavez, Lukas
Okonechnikov, Konstantin
Bertrand, Kelsey C.
Wang, Xiuxing
Erkek, Serap
Federation, Alexander
Song, Anne
Lee, Christine
Wang, Xin
McDonald, Laura
Morrow, James J.
Saiakhova, Alina
Sin-Chan, Patrick
Wu, Qiulian
Michaelraj, Kulandaimanuvel Antony
Miller, Tyler E.
Hubert, Christopher G.
Ryzhova, Marina
Garzia, Livia
Donovan, Laura
Dombrowski, Stephen
Factor, Daniel C.
Luu, Betty
Valentim, Claudia L. L.
Gimple, Ryan C.
Morton, Andrew
Kim, Leo
Prager, Briana C.
Lee, John J. Y.
Wu, Xiaochong
Zuccaro, Jennifer
Thompson, Yuan
Holgado, Borja L.
Reimand, Jüri
Ke, Susan Q.
Tropper, Adam
Lai, Sisi
Vijayarajah, Senthuran
Doan, Sylvia
Mahadev, Vaidehi
Miñan, Ana Fernandez
Gröbner, Susanne N.
Lienhard, Matthias
Zapatka, Marc
Huang, Zhiqin
Aldape, Kenneth D.
Carcaboso, Angel M.
Houghton, Peter J.
Keir, Stephen T.
Milde, Till
Witt, Hendrik
Li, Yan
Li, Chao-Jun
Bian, Xiu-Wu
Jones, David T. W.
Scott, Ian
Singh, Sheila K.
Huang, Annie
Dirks, Peter B.
Bouffet, Eric
Bradner, James E.
Ramaswamy, Vijay
Jabado, Nada
Rutka, James T.
Northcott, Paul A.
Lupien, Mathieu
Lichter, Peter
Korshunov, Andrey
Scacheri, Peter C.
Pfister, Stefan M.
Kool, Marcel
Taylor, Michael D.
Rich, Jeremy N.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5993422
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5993422
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature25169
