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The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cance...

The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cance...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6004450

The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells

About this item

Full title

The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2018-06, Vol.115 (24), p.6225-6230

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Cancer cells are reprogrammed to consume large amounts of glucose to support anabolic biosynthetic pathways. However, blood perfusion and consequently the supply with glucose are frequently inadequate in solid cancers. PEPCK-M (PCK2), the mitochondrial isoform of phosphoenolpyruvate carboxykinase (PEPCK), has been shown by us and others to be funct...

Alternative Titles

Full title

The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6004450

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6004450

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1719871115

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