ATR inhibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D
ATR inhibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D
About this item
Full title
Author / Creator
Komura, Kazumasa , Yoshikawa, Yuki , Shimamura, Teppei , Chakraborty, Goutam , Gerke, Travis A. , Hinohara, Kunihiko , Chadalavada, Kalyani , Jeong, Seong Ho , Armenia, Joshua , Du, Shin-Yi , Mazzu, Ying Z. , Taniguchi, Kohei , Ibuki, Naokazu , Meyer, Clifford A. , Nanjangud, Gouri J. , Inamoto, Teruo , Lee, Gwo-Shu Mary , Mucci, Lorelei A. , Azuma, Haruhito , Sweeney, Christopher J. and Kantoff, Philip W.
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Epigenetic modifications control cancer development and clonal evolution in various cancer types. Here, we show that loss of the male-specific histone demethylase lysine-specific demethylase 5D (KDM5D) encoded on the Y chromosome epigenetically modifies histone methylation marks and alters gene expression, resulting in aggressive prostate cancer. F...
Alternative Titles
Full title
ATR inhibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D
Authors, Artists and Contributors
Author / Creator
Yoshikawa, Yuki
Shimamura, Teppei
Chakraborty, Goutam
Gerke, Travis A.
Hinohara, Kunihiko
Chadalavada, Kalyani
Jeong, Seong Ho
Armenia, Joshua
Du, Shin-Yi
Mazzu, Ying Z.
Taniguchi, Kohei
Ibuki, Naokazu
Meyer, Clifford A.
Nanjangud, Gouri J.
Inamoto, Teruo
Lee, Gwo-Shu Mary
Mucci, Lorelei A.
Azuma, Haruhito
Sweeney, Christopher J.
Kantoff, Philip W.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6025984
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6025984
Other Identifiers
ISSN
0021-9738,1558-8238
E-ISSN
1558-8238
DOI
10.1172/JCI96769