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ATR inhibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D

ATR inhibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6025984

ATR inhibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D

About this item

Full title

ATR inhibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D

Publisher

United States: American Society for Clinical Investigation

Journal title

The Journal of clinical investigation, 2018-07, Vol.128 (7), p.2979-2995

Language

English

Formats

Publication information

Publisher

United States: American Society for Clinical Investigation

More information

Scope and Contents

Contents

Epigenetic modifications control cancer development and clonal evolution in various cancer types. Here, we show that loss of the male-specific histone demethylase lysine-specific demethylase 5D (KDM5D) encoded on the Y chromosome epigenetically modifies histone methylation marks and alters gene expression, resulting in aggressive prostate cancer. F...

Alternative Titles

Full title

ATR inhibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6025984

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6025984

Other Identifiers

ISSN

0021-9738,1558-8238

E-ISSN

1558-8238

DOI

10.1172/JCI96769

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