SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling
SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling
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Author / Creator
Voelkl, Jakob , Luong, Trang Td , Tuffaha, Rashad , Musculus, Katharina , Auer, Tilman , Lian, Xiaoming , Daniel, Christoph , Zickler, Daniel , Boehme, Beate , Sacherer, Michael , Metzler, Bernhard , Kuhl, Dietmar , Gollasch, Maik , Amann, Kerstin , Müller, Dominik N , Pieske, Burkert , Lang, Florian and Alesutan, Ioana
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
Medial vascular calcification, associated with enhanced mortality in chronic kidney disease (CKD), is fostered by osteo-/chondrogenic transdifferentiation of vascular smooth muscle cells (VSMCs). Here, we describe that serum- and glucocorticoid-inducible kinase 1 (SGK1) was upregulated in VSMCs under calcifying conditions. In primary human aortic V...
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Full title
SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6025998
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6025998
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI96477
