Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink appr...
Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development
About this item
Full title
Author / Creator
Publisher
Dordrecht: Springer
Journal title
Language
English
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Publication information
Publisher
Dordrecht: Springer
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Scope and Contents
Contents
The molecular chaperone Hsp90 is one component of a highly complex and interactive cellular proteostasis network (PN) that participates in protein folding, directs misfolded and damaged proteins for destruction, and participates in regulating cellular transcriptional responses to environmental stress, thus promoting cell and organismal survival. Ov...
Alternative Titles
Full title
Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6045531
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6045531
Other Identifiers
ISSN
1355-8145
E-ISSN
1466-1268
DOI
10.1007/s12192-018-0877-2
