Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH
Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Endosomes have emerged as a central hub and pathogenic driver of Alzheimer’s disease (AD). The earliest brain cytopathology in neurodegeneration, occurring decades before amyloid plaques and cognitive decline, is an expansion in the size and number of endosomal compartments. The strongest genetic risk factor for sporadic AD is the ε4 allele of Apol...
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Full title
Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6048470
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6048470
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1801612115
