Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation...
Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis
About this item
Full title
Author / Creator
Maruyama, Tomohiro , Baba, Takashi , Maemoto, Yuki , Hara-Miyauchi, Chikako , Hasegawa-Ogawa, Minami , Okano, Hirotaka James , Enda, Yuki , Matsumoto, Kei , Arimitsu, Nagisa , Nakao, Kazuki , Hamamoto, Hiroshi , Sekimizu, Kazuhisa , Ohto-Nakanishi, Takayo , Nakanishi, Hiroki , Tokuyama, Takeshi , Yanagi, Shigeru , Tagaya, Mitsuo and Tani, Katsuko
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
DDHD2/KIAA0725p is a mammalian intracellular phospholipase A
1
that exhibits phospholipase and lipase activities. Mutation of the
DDHD2
gene causes hereditary spastic paraplegia (SPG54), an inherited neurological disorder characterized by lower limb spasticity and weakness. Although previous studies demonstrated lipid droplet accumulati...
Alternative Titles
Full title
Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis
Authors, Artists and Contributors
Author / Creator
Baba, Takashi
Maemoto, Yuki
Hara-Miyauchi, Chikako
Hasegawa-Ogawa, Minami
Okano, Hirotaka James
Enda, Yuki
Matsumoto, Kei
Arimitsu, Nagisa
Nakao, Kazuki
Hamamoto, Hiroshi
Sekimizu, Kazuhisa
Ohto-Nakanishi, Takayo
Nakanishi, Hiroki
Tokuyama, Takeshi
Yanagi, Shigeru
Tagaya, Mitsuo
Tani, Katsuko
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6056544
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6056544
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-018-0815-3
