α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathie...
α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies
About this item
Full title
Author / Creator
Prots, Iryna , Grosch, Janina , Brazdis, Razvan-Marius , Simmnacher, Katrin , Veber, Vanesa , Havlicek, Steven , Hannappel, Christian , Krach, Florian , Krumbiegel, Mandy , Schütz, Oliver , Reis, André , Wrasidlo, Wolfgang , Galasko, Douglas R. , Groemer, Teja W. , Masliah, Eliezer , Schlötzer-Schrehardt, Ursula , Xiang, Wei , Winkler, Jürgen and Winner, Beate
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
α-Synuclein (α-Syn) aggregation, proceeding fromoligomers to fibrils, is one central hallmark of neurodegeneration in synucleinopathies. α-Syn oligomers are toxic by triggering neurodegenerative processes in in vitro and in vivo models. However, the precise contribution of α-Syn oligomers to neurite pathology in human neurons and the underlying mec...
Alternative Titles
Full title
α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies
Authors, Artists and Contributors
Author / Creator
Grosch, Janina
Brazdis, Razvan-Marius
Simmnacher, Katrin
Veber, Vanesa
Havlicek, Steven
Hannappel, Christian
Krach, Florian
Krumbiegel, Mandy
Schütz, Oliver
Reis, André
Wrasidlo, Wolfgang
Galasko, Douglas R.
Groemer, Teja W.
Masliah, Eliezer
Schlötzer-Schrehardt, Ursula
Xiang, Wei
Winkler, Jürgen
Winner, Beate
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6065020
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6065020
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1713129115
