CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions
CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions
About this item
Full title
Author / Creator
Zimmermann, Michal , Murina, Olga , Reijns, Martin A. M. , Agathanggelou, Angelo , Challis, Rachel , Tarnauskaitė, Žygimantė , Muir, Morwenna , Fluteau, Adeline , Aregger, Michael , McEwan, Andrea , Yuan, Wei , Clarke, Matthew , Lambros, Maryou B. , Paneesha, Shankara , Moss, Paul , Chandrashekhar, Megha , Angers, Stephane , Moffat, Jason , Brunton, Valerie G. , Hart, Traver , de Bono, Johann , Stankovic, Tatjana , Jackson, Andrew P. and Durocher, Daniel
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The observation that BRCA1
-
and BRCA2-deficient cells are sensitive to inhibitors of poly(ADP–ribose) polymerase (PARP) has spurred the development of cancer therapies that use these inhibitors to target deficiencies in homologous recombination
1
. The cytotoxicity of PARP inhibitors depends on PARP trapping, the formation of non-coval...
Alternative Titles
Full title
CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions
Authors, Artists and Contributors
Author / Creator
Murina, Olga
Reijns, Martin A. M.
Agathanggelou, Angelo
Challis, Rachel
Tarnauskaitė, Žygimantė
Muir, Morwenna
Fluteau, Adeline
Aregger, Michael
McEwan, Andrea
Yuan, Wei
Clarke, Matthew
Lambros, Maryou B.
Paneesha, Shankara
Moss, Paul
Chandrashekhar, Megha
Angers, Stephane
Moffat, Jason
Brunton, Valerie G.
Hart, Traver
de Bono, Johann
Stankovic, Tatjana
Jackson, Andrew P.
Durocher, Daniel
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6071917
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6071917
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-018-0291-z
