Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome
About this item
Full title
Author / Creator
Jimenez-Vargas, Nestor N. , Pattison, Luke A. , Zhao, Peishen , Lieu, TinaMarie , Latorre, Rocco , Jensen, Dane D. , Castro, Joel , Aurelio, Luigi , Le, Giang T. , Flynn, Bernard , Herenbrink, Carmen Klein , Yeatman, Holly R. , Edgington-Mitchell, Laura , Porter, Christopher J. H. , Halls, Michelle L. , Canals, Meritxell , Veldhuis, Nicholas A. , Poole, Daniel P. , McLean, Peter , Hicks, Gareth A. , Scheff, Nicole , Chen, Elyssa , Bhattacharya, Aditi , Schmidt, Brian L. , Brierley, Stuart M. , Vanner, Stephen J. and Bunnett, Nigel W.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Once activated at the surface of cells, G protein-coupled receptors (GPCRs) redistribute to endosomes, where they can continue to signal. Whether GPCRs in endosomes generate signals that contribute to human disease is unknown. We evaluated endosomal signaling of protease-activated receptor-2 (PAR₂), which has been proposed to mediate pain in patien...
Alternative Titles
Full title
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome
Authors, Artists and Contributors
Author / Creator
Pattison, Luke A.
Zhao, Peishen
Lieu, TinaMarie
Latorre, Rocco
Jensen, Dane D.
Castro, Joel
Aurelio, Luigi
Le, Giang T.
Flynn, Bernard
Herenbrink, Carmen Klein
Yeatman, Holly R.
Edgington-Mitchell, Laura
Porter, Christopher J. H.
Halls, Michelle L.
Canals, Meritxell
Veldhuis, Nicholas A.
Poole, Daniel P.
McLean, Peter
Hicks, Gareth A.
Scheff, Nicole
Chen, Elyssa
Bhattacharya, Aditi
Schmidt, Brian L.
Brierley, Stuart M.
Vanner, Stephen J.
Bunnett, Nigel W.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6077730
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6077730
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1721891115
