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Reversal of IDO-mediated cancer immune suppression by systemic kynurenine depletion with a therapeut...

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Reversal of IDO-mediated cancer immune suppression by systemic kynurenine depletion with a therapeut...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6078800

Reversal of IDO-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme

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Elevated tryptophan (Trp) catabolism in the tumor microenvironment (TME) can mediate immune suppression by upregulation of IFNg-inducible indoleamine 2,3-dioxygenase (IDO1) and/or ectopic expression of the predominantly liver-restricted enzyme tryptophan 2,3-dioxygenase (TDO)
1
–
5
. Whether these effects are due to Trp depletion in the...

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Full title

Reversal of IDO-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme

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Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6078800

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6078800

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ISSN

1087-0156

E-ISSN

1546-1696

DOI

10.1038/nbt.4180

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