Recombinant Listeria promotes tumor rejection by CD8⁺ T cell-dependent remodeling of the tumor micro...
Recombinant Listeria promotes tumor rejection by CD8⁺ T cell-dependent remodeling of the tumor microenvironment
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Agents that remodel the tumor microenvironment (TME), prime functional tumor-specific T cells, and block inhibitory signaling pathways are essential components of effective immunotherapy. We are evaluating live-attenuated, double-deleted Listeria monocytogenes expressing tumor antigens (LADD-Ag) in the clinic. Here we show in numerous mouse models...
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Full title
Recombinant Listeria promotes tumor rejection by CD8⁺ T cell-dependent remodeling of the tumor microenvironment
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6094133
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6094133
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1801910115
