MASTL overexpression promotes chromosome instability and metastasis in breast cancer
MASTL overexpression promotes chromosome instability and metastasis in breast cancer
About this item
Full title
Author / Creator
Rogers, Samuel , McCloy, Rachael A. , Parker, Benjamin L. , Gallego-Ortega, David , Law, Andrew M. K. , Chin, Venessa T. , Conway, James R. W. , Fey, Dirk , Millar, Ewan K. A. , O’Toole, Sandra , Deng, Niantao , Swarbrick, Alexander , Chastain, Paul D. , Cesare, Anthony J. , Timpson, Paul , Caldon, C. Elizabeth , Croucher, David R. , James, David E. , Watkins, D. Neil and Burgess, Andrew
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
MASTL kinase is essential for correct progression through mitosis, with loss of MASTL causing chromosome segregation errors, mitotic collapse and failure of cytokinesis. However, in cancer MASTL is most commonly amplified and overexpressed. This correlates with increased chromosome instability in breast cancer and poor patient survival in breast, o...
Alternative Titles
Full title
MASTL overexpression promotes chromosome instability and metastasis in breast cancer
Authors, Artists and Contributors
Author / Creator
McCloy, Rachael A.
Parker, Benjamin L.
Gallego-Ortega, David
Law, Andrew M. K.
Chin, Venessa T.
Conway, James R. W.
Fey, Dirk
Millar, Ewan K. A.
O’Toole, Sandra
Deng, Niantao
Swarbrick, Alexander
Chastain, Paul D.
Cesare, Anthony J.
Timpson, Paul
Caldon, C. Elizabeth
Croucher, David R.
James, David E.
Watkins, D. Neil
Burgess, Andrew
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6095835
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6095835
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-018-0295-z
