NKX3-1 is required for induced pluripotent stem cell reprogramming and can replace OCT4 in mouse and...
NKX3-1 is required for induced pluripotent stem cell reprogramming and can replace OCT4 in mouse and human iPSC induction
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Using a heterokaryon system, Mai et al. demonstrate that NKX3-1 is downstream of IL-6–STAT3, regulates endogenous OCT4 expression during human iPSC reprogramming, and can also substitute for exogenous OCT4 in the reprogramming cocktail.
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) is now routinely accomplished by overexp...
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NKX3-1 is required for induced pluripotent stem cell reprogramming and can replace OCT4 in mouse and human iPSC induction
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6101038
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6101038
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-018-0136-x
