A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in no...
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade
About this item
Full title
Author / Creator
Thommen, Daniela S. , Koelzer, Viktor H. , Herzig, Petra , Roller, Andreas , Trefny, Marcel , Dimeloe, Sarah , Kiialainen, Anna , Hanhart, Jonathan , Schill, Catherine , Hess, Christoph , Savic Prince, Spasenija , Wiese, Mark , Lardinois, Didier , Ho, Ping-Chih , Klein, Christian , Karanikas, Vaios , Mertz, Kirsten D. , Schumacher, Ton N. and Zippelius, Alfred
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Evidence from mouse chronic viral infection models suggests that CD8
+
T cell subsets characterized by distinct expression levels of the receptor PD-1 diverge in their state of exhaustion and potential for reinvigoration by PD-1 blockade. However, it remains unknown whether T cells in human cancer adopt a similar spectrum of exhausted states...
Alternative Titles
Full title
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade
Authors, Artists and Contributors
Author / Creator
Koelzer, Viktor H.
Herzig, Petra
Roller, Andreas
Trefny, Marcel
Dimeloe, Sarah
Kiialainen, Anna
Hanhart, Jonathan
Schill, Catherine
Hess, Christoph
Savic Prince, Spasenija
Wiese, Mark
Lardinois, Didier
Ho, Ping-Chih
Klein, Christian
Karanikas, Vaios
Mertz, Kirsten D.
Schumacher, Ton N.
Zippelius, Alfred
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6110381
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6110381
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/s41591-018-0057-z
