Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons
Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons
About this item
Full title
Author / Creator
Shi, Yingxiao , Lin, Shaoyu , Staats, Kim A , Li, Yichen , Chang, Wen-Hsuan , Hung, Shu-Ting , Hendricks, Eric , Linares, Gabriel R , Wang, Yaoming , Son, Esther Y , Wen, Xinmei , Kisler, Kassandra , Wilkinson, Brent , Menendez, Louise , Sugawara, Tohru , Woolwine, Phillip , Huang, Mickey , Cowan, Michael J , Ge, Brandon , Koutsodendris, Nicole , Sandor, Kaitlin P , Komberg, Jacob , Vangoor, Vamshidhar R , Senthilkumar, Ketharini , Hennes, Valerie , Seah, Carina , Nelson, Amy R , Cheng, Tze-Yuan , Lee, Shih-Jong J , August, Paul R , Chen, Jason A , Wisniewski, Nicholas , Hanson-Smith, Victor , Belgard, T Grant , Zhang, Alice , Coba, Marcelo , Grunseich, Chris , Ward, Michael E , van den Berg, Leonard H , Pasterkamp, R Jeroen , Trotti, Davide , Zlokovic, Berislav V and Ichida, Justin K
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Human ALS/FTD patient iPSC-derived neurons are used to uncover mechanisms by which C9ORF72 mutations cause neurodegeneration.
An intronic GGGGCC repeat expansion in
C9ORF72
is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the pathogenic mechanism of this repeat remains unclear. Using hu...
Alternative Titles
Full title
Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons
Authors, Artists and Contributors
Author / Creator
Lin, Shaoyu
Staats, Kim A
Li, Yichen
Chang, Wen-Hsuan
Hung, Shu-Ting
Hendricks, Eric
Linares, Gabriel R
Wang, Yaoming
Son, Esther Y
Wen, Xinmei
Kisler, Kassandra
Wilkinson, Brent
Menendez, Louise
Sugawara, Tohru
Woolwine, Phillip
Huang, Mickey
Cowan, Michael J
Ge, Brandon
Koutsodendris, Nicole
Sandor, Kaitlin P
Komberg, Jacob
Vangoor, Vamshidhar R
Senthilkumar, Ketharini
Hennes, Valerie
Seah, Carina
Nelson, Amy R
Cheng, Tze-Yuan
Lee, Shih-Jong J
August, Paul R
Chen, Jason A
Wisniewski, Nicholas
Hanson-Smith, Victor
Belgard, T Grant
Zhang, Alice
Coba, Marcelo
Grunseich, Chris
Ward, Michael E
van den Berg, Leonard H
Pasterkamp, R Jeroen
Trotti, Davide
Zlokovic, Berislav V
Ichida, Justin K
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6112156
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6112156
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4490
